Retrosynthetic polyketide disconnections for unnatural aromatics
نویسندگان
چکیده
Polyketide synthases are extraordinarily complex enzymatic machineries that govern the assembly and cyclization of poly-β-carbonyl intermediates to an enormous diversity natural products. Captivatingly, this biosynthetic strategy is transferable retrosynthetic analysis unnatural aromatics, enabling strategic biomimetic polyketide cyclizations design extensive range otherwise unrelated aromatic
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ژورنال
عنوان ژورنال: Trends in chemistry
سال: 2022
ISSN: ['2589-5974', '2589-7209']
DOI: https://doi.org/10.1016/j.trechm.2022.01.013